Instead of focusing on the next big thing, consider focusing on things that won't change. Focus on substance instead of fashion.
Amazon focuses on fast shipping and affordable prices, because there's no way that in 20 years people will wish shipping was slower or prices were higher, this focus will always give them an advantage.
37signals focus on speed, simplicity, ease of use, and clarity.
Fashion fades away. When you focus on fundamental things your product will never go out of style.